i would choose mass effect 3.
I'm in love with the in depth story from the trilogy and how they were all connected and eventually the choices that you made on previous games finally had a closure. All the major problems were resolved in a happy ending or could end up terribly if you have a renegade file. Some of the scenes were so touching and sad that it made my eyes watery for the first time in video games...
The character development throughout the whole trilogy was amazing and in my opinion, the best in this generation. All of the characters that I can remember made some kind of a impact towards the final mission in the galactic war assets, which made me happy of all my choices that I've made with my paragon and renegade files.
The game play itself was very similar to mass effect 2, but it was more fun with new power skills. The multiplayer got me clocked in for over 70+ hours, which is now boring, but it is fun to play it once a while with my friends.
The ending made a lot of fans disappointed including myself, but the added scenes made things a little bit better. Overall, I thought it was a good closure to the best trilogy in the world. I will always love the mass effect universe and I'm sad that the story of Commander Shepard is over.