Personally, I liked both
Fluxx! and
Apples to Apples as a great card game, though I do recommend playing them with atleast 4+ people to get the full experience
Also, might I suggest the
Chair Game? It's like a reverse Jenga, where you work to stack odd shaped chairs on top of each other, trying to eliminate your pool of chairs.
There is another card game that you could play in "solitaire" called
Chrononauts. I've had some friends recommend this game, but I myself haven't played it.