Originally Posted by Argive
Mass Effect is essentially a KOTOR sequal without the Star Wars license. Just ask yourself if you want to play an older Mass Effect with less eye candy but with star wars. Note: there isn't any indication of the awful ME1 inventory system. I don't know what possessed bioware with that one.
ME and KOTOR play nothing alike though...
The gameplay in KOTOR is more along the lines of Dragon Age.
Storywise and characterwise, it's still among one of Bioware's best.