Selling the game may not be profitable, but if you pre-ordered several copies of the game and got artbooks, and then sold the games and artbooks on ebay, then yes, you could actually make a small profit. Would it be worth the time and hassle involved? That depends on each person.
Everybody loves to complain about ebay, but if you are SMART and know what you are doing, you can actually do well. For example, you may have to pay ebay fees, paypal fees, etc., but there are some things where ebay really is the only way to go (NOT xenoblade chronicles, because that has more widespread appeal). For example, try to sell some weird niche titles or very obscure items through craigslist in a relatively small town and see how successful you'll be. Ebay, despite fees sucking, is sometimes the only way to reach a wide enough audience to sell certain things.
Not really the case with Xenoblade, but just saying, heh.