The Vampire point is grossly inflated. The game itself already requires most people to do a lot of steps to get it to run well already. The step described by MysterD takes like 2 seconds, which is pretty small in the world of getting that janky bug ridden mess to run well.

Fallout 3 makes no sense either. That's a GFWL game, and the Steam DRM has no affect on it. There's a reason why it's much easier to mod Fallout New Vegas and not lose access to save files over Fallout 3. Mod a game 10 hours in that has script changes in New Vegas, you're fine. Do the same to 3, which GFWL detects as a cheat program, and your save files are no longer accessible.