Two months ago we reviewed iolo's System Mechanic v.10.5, which is one of the better ways to get your PC in top working order:
http://www.tech-gaming.com/?p=2298
Beyond a slow disk fragmentation component and the inability to remove orphaned install folders, System Mechanic is one of the best clean-up utilities on the market. The obsessive compulsive neat-freak/optimization-nut in me as tried them all, from paid apps like Tune-up Utilities to freebies like CCleaner.
Ordinarily, I'd make you listen to our entire podcast for details on how to enter, but I'd taught I'd give our friends at CAG a little time-saver.
Simply, post one of System Mechanics functions (such as registry cleaning, start-up maintenance) in this thread:
http://www.tech-gaming.com/?p=2746
For those interested in listening to the show, thanks in advance. I think you'll like it