Game content wise usually not, unless they add DLC or other crap for the re-release. It's not really a big deal, I'd just rather not have the uglified artwork and case. Just anal.
Well I decided to bite on the Saints Row 2 offer and got it today. First time buying from this place and I got a Platinum Hits version. I wasn't even aware there was a PH version, guess I should have done more research. If anyone else cares about this sort of thing, take note, yay for misleading...