Yeah, I just realized you were the friend request I received recently and how the hell did you get such a high score on Biolab?!?
Multiball over and over, plus going for those modes, but I'm not sure how much they factored in. Probably not insignificant, but getting lots and lots of jackpots and super jackpots is good.
In any case shooting the main shot up there is safe and will get you modes, so you might as well shoot it. The hardest mode to complete is that damned skill shot one. Really sucks when you get to the second set and you have to get 4 skill shots instead of 3 (at least 4 - I got 3 but not 4 the second time). Ouch. Don't forget to bump to coerce the ball into the skill shot. Doesn't always work, but if it's going to be a miss you might as well bump the thing.
Second hardest mode is the 2-ball multiball one where you have to repeat shots. That is, shoot some shot and that shot lights for a period of time and you need to shoot the same shot again within the time limit. Two shots can be lit at a time. I forget how many you have to complete to finish the mode. The other modes are easy. The one about building your strength wasn't obvious to me at first. Just shoot the "stand up targets" that are lit. The easiest ones to hit are the weird face-with-three-eyes thing in the middle of the playfield. Hit that a bunch of times and you'll complete the mode.
Also worth noting about that weird face thing: During normal play one of the eyes is lit. If you hit the lit eye, some other shot on the playfield lights for a while. If you shoot that before it times out you get a kickback lit. That's worth doing. It's not worth trying to get it started, but if you hit it by accident and a shot gets lit as a result, go for that shot, especially if it's the left ramp, which is a relatively easy shot. I think the shots are left ramp, right loop and the upper loop (going to the right), but don't quote me on it. I usually don't bother trying to get that upper loop. It's hard to do that one.
The wizard mode is pretty straight forward. You have to complete (successfully) all the modes to get to it, then start the next mode and it will be the wizard mode. There's 3 stages to the wizard mode. To get the achievement you have to complete all 3 stages.