No. AC2 onwards all require Uplay. Uplay is no longer the always online nightmare it used to be. Now it is one-time verification for most titles. Don't let Uplay stop you from enjoying AC2, ACB, & ACR.
With the caveat that there are still a couple of always online games like Settlers 7 and HAWX 2 I believe.
Also running some games in offline mode may lose you access to certain extra modes and items and such. I know M&M Heroes 6 and Anno 2070 is like this. I think for AC though you just lose Ubi achievments so eh.
Those I suppose you can rack up enough credits with those to get DLC for free so there's that.
But anyway yeah it's not as bad as it used to be. You do need to make sure you do the initial activation though because those UPlay servers have been known to go down some times and if you haven't run it at least once and happen to want to start when their servers are down (it's rare but it happened to me once) then you will be out of luck.
Strange, I've bought several things from 2K over the past year (including Spec Ops a couple of weeks ago), yet I haven't received any emails about it. Got about 40 emails about getting a discount for EA games, but nothing for 2K or any other publisher that I've bought over the past year.
They are working on filling the emails. The 2K ones will probably come last so if not today then some time tomorrow probably. The 2K deal will be on 12/26. The others EA THQ and Ubi should be tomorrow.
There's a lot more chatter about it, along with bitching and moaning
, in the Amazon thread.