I've read quite a few comics on my iPad and I like it just fine. It's not a replacement for reading printed comics, mind, but it does the job and does it conveniently. It's nice to not have to worry about bending covers or anything like that.
Cost-wise, more often than not single issues will cost the same as single issues in print (they usually drop in price after a certain point). Marvel and DC have started including digital copies of (several but not all of) their books in with the print versions, which is a nice bonus.
I can't speak to the Kindle Fire or Nook Color - maybe they don't work as well with comics - but my tablet experience with comics has been just dandy.