So I was listening to the show this morning on the way to work and I thought of an acceptable way (in my opinion) for Microsoft or Sony to discourage used game sales/reselling games: Give me the option of installing the game to the system's HDD and never need the disc again.
(Currently Microsoft lets you install but you need to have the disc inserted to play which sorta defeats the purpose/real convenience factor.)
In the scenario I've conjured up if I don't install it, the game is just as it would be in this gen; I can resell it and someone can buy it used no problem. It solves the concern of buying blind or sample without being able to resell and wouldn't decimate the used market completely. Then if it turns out I like the game and choose to install it, I lose the option to resell but can play directly off the HDD.
Publishers could (I suppose) tie installation to extras akin to the Online Pass or free DLC to incentivize this. But hey if it's a game I like I'm OK with that.
To continue into wild speculation territory perhaps Sony/Microsoft tie installation to being able to stream the game (via Gaikai or something similar) to another system/device or TV freely if you're signed in. I'd be OK with that too.
Point is, the "Next-Gen Systems to Prevent/Block Used Games" is an eye-catching, bleak and terrible headline that no one wants. But, like Online Passes etc. I am sure it could be done in a way that encourages permanent ownership and discourages reselling with some useful incentives.