Yeah I had the exact same thing happen to me. I took the game into gamestop where I had bought the system and they gave me a new "retail" copy of RE5 and it works fine now.
For some reason my red xbox wont play the Resident Evil 5 Disk it came with? I put it in and it trys to read it and then it just acts like theres no disk in. It plays all my other games fine though. Anyone else have this problem?
looks like on some of these they recycled the old elite box and just put a cover around it. Mine was not like that.
http://www.youtube.com/watch?v=cJ78slcXX-w