imo (only back to 6th generation):
- Skies of Arcadia
- Tales of Symphonia
- Shadow of the Colossus
- Super Smash Bros. Melee
- ICO
- Zelda: Twilight Princess
- God of War I & II
- Super Mario Galaxy
- etc.
- etc.
There are a lot of great games in the past, list would be too big. :P