In the past five years, all I've used is a Deathadder and a G5. Unfortunately, Logitech no longer makes the G5. The Deathadd though is a fantastic mouse. It's got your pretty standard five button layout that's rpetty common these days (left/right click, middle mouse, and mouse 4 and 5). Aside from that retarded Razer mouse already posted, not sure of any others that offer more than the five button layout.