Personally, I wish Disney could just reel in all of the Marvel film licenses, so that they can connect to main Marvel movie line (Iron Man, Incredible Hulk, Thor, etc.). Not in blatent ways, like having some ultimate team up thing (Though my inner geek thinks that would be super-mega-rad!), but it would be cool if we could see something like Tony Stark having a quick conversation with Reed Richards, or maybe see a news report on Spider-Man in the background of a scene. Just little things to make all the movies feel like they're taking place in a cohesive universe.
Also, on the subject of multiple villains in a movie, I always wish they could handle it more sensibly. I'd like to have seen something like this in one of the Spidey sequels: Movie starts in the middle of some sort of robbery being led by a thug-type villain, like Electro, Vulture, or Shocker. One of those villains that really couldn't carry a full film, but would be fun to see. Spidey swings in, there's a brief fight, and the villain ends up webbed to a wall, or hanging from a lamp post. Spidey swings away, main title comes up, and then we move into the main plot with whatever mastermind villain taking the spotlight. That way, we get to introduce other villains into the Spidey-verse without having to waste the whole movie on them. It would have been a great way to build up to a Sinister Six movie. Oh well.