I'm echo what the squatch said. It'll depend and sometimes it is noticable sometimes not. I have a giant case and run 2 NVMEs (1 PCI 4 (Samsung 980), 1 PCI 3 (Gigabyte)), I also have a Samsung 970 Evo SSD, Toshiba 5TB HDD, and a bunch of Hitachi refurb 7200s. The jump between the HDD, SSD...