Depending on budget:
Two new desktops (both my GF's and mine were built when FFXI came out, with the video cards upgraded and hdd space (mine has about 0.7TB), but not much beyond that). Thinking about i7s at least, and 2-8TB for my system, and at least 1-2TB on GF's, RAIDed (mine usually acts as a file server anyways, so no reason for both of us to have that much space).
A new TV. Our 37" 720p is still awesome, imo, and all, but I did originally buy that with the intention on getting a bigger one when we had much more money, and replacing our old CRT in the bedroom with the 37". And I wouldn't go for anything 42" or below, so this will likely be next year.
Some games. Depending on what, since I'm finding myself pretty satiated as far as current gen games go. I still haven't opened Dragon Age Origins I bought last year. So unless there's something that we really want and still don't have, probably not too much in this department (i.e. Alan Wake LE for under $40, Heavy Rain and Katamari Forever for $20, StarCraft 2 SE for $50 or less since I don't see any at Targets near me).
DVDs and Movies. Well, I'm pretty much caught up on my collections, but I do want Entourage, House S6 for under $35 (because it's the worst season so far, so I'm not paying a penny more), and I want to get Honey and Clover for the GF. If the Lucky Star SEs are on sale like Haruhi SEs were, I'd probably buy them. Not much other than those.
Last, but not least. A 32GB MicroSD card for under $100. I didn't buy one with my Droid X, so I'm really hoping to see a legit one for $100 or less. I lose connection in my office about 30-40% of the time, so I have to listen to music loaded on it. After a few weeks, I'm getting bored of the 5-6gigs I loaded on it, so I'd love a 32GB MicroSD, which can hold about 80% of my MP3s.