FASA is currently out of business for one reason or another, shadowrun is being produced by one company. Their other games are produced by other companies, the names of which I don't remember. As far as I know, the genisis game and the SNES game are identical. I played both of them, didn't notice any differences. Also, if anyone is playing the game, thinking it's wonderful, and deciding to play the pen and paper RPG, it's significantly different. It's still great, but don't base your opinions off of the SNES/genisis game.
Also, the wachowski brothers drew from many sources, including some crazy lady, FASA, and Plato, the philosopher.