Well E3 is bound to bring lots of suprises, but not taken that into account I would have to say
Between Spring and Summer ? Moto GP and Dead Rising. Everyone is looking forward to Dead Rising on this board, well not everyone but a good majority. Moto GP is going to be pure quality that I can gurantee, but that game isn't going to be for everyone and that includes me. Maybe people will say Battlefield 2 or Final Fantasy, but one is a port and the other is a polished port and neither are new experiences that will blow my mind away.
Fall? Could be anything at this point. But my two guesses are Gears of War Splinter Cell Double Agent. Looking forward to both.