If you dig up the old DR2 thread in this forum, I think a lot of the players were getting a few hours into the game, then restarting from the beginning and keeping their leveled character. That means you can take out some of the enemies a little faster and effectively fight the clock.
Personally, as soon as I saw people doing that, i sold it.
That said- they are about to re-release the game with Frank West in the lead, so you might want to just wait and play that version of the game.