Mass Effect 3 won't be released in 2011, based on previous releases in the series. I know some of the assets are there, but I just can't see it happening.
I would have a heart attack if Diablo III got released in 2011, but I guess crazier shit has happened. They delay EVERYTHING.
Those two are easily my most anticipated, if somehow they were released. Impossible to narrow it down.
Realistically: Deus Ex Human Revolution