I finished my first PT at lvl 33. I was able to run through the main story line of PT2 at about the right level the whole time, saving all my side quests for 2.5
OK, someone explain to me the significance of playthrough 2.5? I keep seeing that mentioned. Why wouldn't you get everything else done on playthrough 2? I started TVHM last night and gained like 3 levels just getting to Sanctuary, so I don't think it will be a problem to hit 50. What (or why) are you saving anything for 2.5?
Also, some Wiki I was reading said you don't get the "You Will Die" (Terramorphous?) mission until you beat the game the second time. I got it after I beat it the first time. Of course it said it was level 50 and impossible so I didn't try it, but it is there in any case.
And by the way, it is not so straightforward to start up a TVHM game - thanks (not) to those who (didn't) answer my question about that earlier . You have to ditch your current character and then reselect it to get that option. Starting a new game doesn't give you the option. But when I started a new character, realized I didn't want to start from scratch, then went back to my last character, it finally gave me the option. So, yeah, akward UI design there, but whatever...