DisneyQuest and the Tomorrowland Light and Power Company (the Space Mountain arcade) are both great, as mentioned, and DisneyQuest is a particularly good deal with the year-long pass.
There's an arcade inside Universal's CityWalk that's supposed to be really top-notch, but I've never been.
On Del Verde Way, which is just off International Drive in the Southwest part of town, I believe, there's a big amusement center called
Fun-Spot, which has a 10,000 foot arcade and four
bad-ass, mostly elevated go-kart courses.
Side note, if you ever happen to stay at Disney's Fort Wilderness Resort, they have a couple very small arcades there.
And really, they're just little shacks, no more than a 15 machines or so. There's one next one of the pools, that I played at when I was way younger. They had Starblade and WaveRunner and a bunch of good stuff. Good memories.
It's too bad the Pac-Man Cafe closed down. It wasn't always the Pac-Man Cafe, and it wasn't always run by Namco. When it first opened, it was called
XS Orlando. I never went, but my dad went not long after it opened, and he just raved about it. It was this really, really high-tech nightclub/arcade combo, really over-the-top with the tech, he told me. Shame; guess I'll never get to go.