My gf is from Ra-cha-cha as she calls it and having been there numerous times in the last 5 years (some of my boys from High School went to college out there) I've learned a couple things:
1. The accent is horrible, but you'll get used to it in 2 years. You'll know it when you hear it.
3. Bathtub Billy's and Nick Tahoe's are great, but don't forget Jay's Diner (West Henrietta Rd., founded by the brother of the Nick Tahoe's owner) and Dinosaur Bar-B-Q.
4. Abbot's. This stuff is killer. Ask and you will know what all the hoopla is about.
5. Lake effect snow. 12 inches daily is the norm, I reckon.
6. Did I mention the accents?
7. Video game stores: you've got a couple of nice malls in the area: Marketplace, Greece Ridge, and Victor. In my experience, Victor Mall is pricey, Marketplace has poor selection, and Greece Ridge has been where I've gotten the best deals. There's a CC in it, too, which helps. Plus, you'll find your bevy of FYE's, Gamestops, EB, and a Media Play I think further down on Ridge Road.
8. City economy: When people say Rochester, think Kodak and Xerox. Both have been in somewhat financial dire straits in the last decade or so, and numerous layoffs have spurred some malcontent in the city. However, as large, multi-national companies go, these two aren't awful for driving money into the city so be thankful that you'll at least have these companies to keep wages up and employment competitive (which in reality is a good a thing).
9. Enjoy High Falls and the Brewery.
10. If you are like me and frequently abuse your gullet and liver, try doubling up on Garbage Plates after a full night o' pounding Genny Lights. I guarantee you that you won't do that again for at least a week thereafter.