Definitely worth it.
Just know that you need to persevere through the relatively awful first five episodes (when Fox was tinkering extensively) to get to the good stuff. But once it picks up (and it's even better this season), Dollhouse becomes one hell of a great show. Season 2 has been one of the best TV seasons I can remember, but you need to watch season 1 for season 2 to work in this show - so it's probably worth it just for that.
I netflixed the Epitaph One/Unaired Pilot disc and I remember the quality being decent (better than, say, Chuck's Blu) but not as strong as Lost.