Only had a few freezes, late in the game, on my playthrough where I did every single mission for the all the main game + DLC. I save on a regular basis, plus it auto saves when you enter buildings and fast travel so I never had much of a problem with it. Great game at this price, and unless you like to wander around in the desert for hours on end and not save, a few glitches shouldn't keep you from playing such a great game.