[quote name='John Hyperion']Jesse, I think all you'll have to do is format the new drive when you put it in the PS3 (and it'll ask you to do this automatically). I don't think anything, like games or movies, is pre-loaded on the PS3 drives when you get it.
Now if you start putting stuff on there you will have to back it up to a FAT32 formatted USB connectable drive of some sort.[/quote]There aren't any items pre-installed on the PS3's internal drive, no.
There's a zillion guides out there on how to do it, and I think there's one or more of them in our PS3 forums, but the gist of it is:
1) Plug in a blank USB drive, hard drive or flash drive, formatted FAT32, with enough capacity to back up what you have on the PS3's internal drive.
2) The PS3 should see the external drive and ask if you want to use it to backup your internal drive.
3) Back up everything to the external drive.
4) Once done, swap out the existing drive for the new drive.
5) Power up the PS3 and have it recognize that the new hard drive needs to be formatted, and format it.
6) Plug in the USB drive used for backup and restore everything to the internal drive.
You don't lose anything when you back everything up and restore it.
Again, if you search for "PS3 hard drive replacement" or "PS3 hard drive upgrade", or something like it, you'll find plenty of guides on the steps needed to do it.