There are a few bitchy operations later (If you aren't careful, hemorrhages will tear through your patient like Lu Bu.) and the tougher Stigma encounters can pretty much one-shot KO the patient if you let slip your guard enough to let them attack, but, for the most part, the game isn't too much harder than the original.
There are a few gameplay procedures that just aren't specified, though, but, TC vets had to learn them through blind feeling back in the original. (Aneurysm whack-a-mole tactics, etc.)