I want to say no offhand for two reasons: 1) Not listed on a retailer website, and 2) Not listed on Seagate's website either (which is what I looked up).
However, on Seagate's site, it says this: "Operating Systems not listed here may provide device drivers for USB mass storage devices." What that makes me think is, given the notorious simplicity of Apple, that maybe there's a standard USB driver that would work with this. Now, I don't
know that per se, but Apple's OS works plug-n-play much better than Windows ever possibly could, so the best answer would be to test it. Maybe if you go B&M you could ask them to hook it up right then and there.
I praise Seagate, though I've never used an external drive they make themselves. I'm hoping they are smart enough to put adequate cooling. Otherwise you could do like I mentioned to Vinny - just keep a fan on it if it ever felt like it was getting too hot. You could also get one of those "coolpad" things people make for laptops, but I don't know how effect they are. And besides, it might be fine without that.
So I'm leaning like...70-30 it will work versus not. It might just be that they didn't test it given past instances, hard to tell. Sounds like they are saying "we're confident it will if drivers exist beforehand, we're not going to make them ourselves." Which means if no Apple equivalent exists, in a month or two you can expect someone to have hacked one out on Sourceforge or something. Which means if it doesn't work
now, you can almost fully expect it to work within a few months.
Not a great answer, I know, but that would be my assumption. People make drivers for
fun these days. I still play video games.