[quote name='icedrake523']I downloaded Sin & Punishment to my SD card since I didn't have room. Then I made room and downloaded it to my Wii. Is it possible to delete it off the memory card?[/QUOTE]
You downloaded it to your SD card. Then did you download it again from the Shop Channel? You didn't have to do that, you could have moved it from your SD card.
Go into data management in your Wii menu, choose channels, then pick your SD card. It will show all the games and channels on your SD card. When you find S&P you can choose to delete it or move it. Since it's already on your internal memory, just delete it. You could choose to move it in the future if you feel that's easier than re-downloading it.