edit - MysterD, I saw this thread and immediately thought of you.
(First Time Play) Vampire the Masquerade. Any Tips?
1. Use Wesp's Unofficial Patch: Basic Version or Tessera's True Patch on PlayThrough 1 (PT1).
First off, you'll need one of those patches to flat-out boot-up the game anyways. Also, those two patches mostly have bug fixes and a few changes/restorations. You can save any other mods or Wesp's Unofficial Patch: Plus Version for PT2 or above. If you have V:TM-B on GOG, just do Wesp's UP Basic on PT1; it comes equipped with that anyways.
2. Don't play as Malkavian on PT1.
Malkavian's are bat-crap crazy - they have their own lingo and speak in riddles, metaphors, and whatever else...so their lines are different than ALL the other classes. You might not even understand what the original dialogue line was, unless you know the game very well. Also, they talk to stop-signs, talk to other inanimate objects, hear voices, interrupt things - as entertaining as this is, that might be better suited to deal w/ on a later PT.
3.
Don't play as Nosferatu on PT1.
You have a limited amount of Masquerades you can break. Break enough of them, game over. If you even get spotted by a human b/c you're so ugly and hideous as a Nosferatu, you're going to violate the Masquerade. And you'll likely get attacked, too. You're likely going to stick to the sewers to move around the game-world, if you go Nosferatu...so you don't get spotted by anyone. Sure, there are times when you can redeem the Masqeurades and do something very humane to replenish a Masquerade - but you're better suited playing that type of character on a replay. Also, stealth approach isn't for everyone and Nosferatu are best-suited for that approach. Yeah, stealth approaches aren't always the most action-packed and not always the most straight-forward - so this character isn't for everyone.
4. Back 1/3rd of the game is an action-fest.
When you decide who you side with (trust me, you'll know when this happens), I'm going to hope you already have sunk lots of points already in Action skills (combat, magic, guns, defense, etc). If not, you should do so...ASAP. And hopefully, it ain't too late b/c the game can get tougher in the last 1/3rd.