I was a huge fan of FC1. I bought this on Xbox 360, and just couldn't get into it. The biggest problem is the malaria. That was an unnecessarily element of "realism" they put in the game that flat out makes the game less fun.
If you haven't played it, imagine a game that's pretty fun, only every so often, it becomes not fun, and you have to look around for medicine to cure the malaria, and make the game fun again. Several of the reviews on major sites mentioned this also.