What sucks is that del Toro has an eye for quality, and could very well produce a quality game with a great developer on board, like Kojima for example. It's clear with P.T. that him and Kojima had something special. I hate to see him never see his vision fulfilled.
I wouldn't doubt some major studios try to get him on board for a game. But I imagine he'll want to work with a company that wont end up scrapping their games.