German newspaper suggests Q1 2011 release in European territories.
It also suggests a 200€ price point, which is roughly $270. I'm still thinking $249.99 is going to be the launch price, but this is just my speculation. No one knows where the paper got their details from, so it could just be speculation on their part.
GoNintendo also suggested that NoA knows "virtually nothing" about the press conference on Wednesday, which points to no NA details showing up (although who the hell really knows, NoA seems pretty clueless or intentionally secretive regarding NoJ details).
My prediction: Comes out in Japan in November for roughly 25,000 yen, launches with maybe a dozen titles with one or two being worthwhile but most likely ports, launches in America by March 2011 with maybe a few more titles, and may or may not launch in European territories shortly thereafter.
My thinking is that Nintendo knows that the Wii only has one real viable holiday season left, and that sales have dropped within the last few months. Given that, they'll want to salvage their earnings reports for the fiscal year, so they HAVE to get it out by the end of March 2011. So they'll shift their profits and revenue directly onto the 3DS to keep themselves looking pretty while the DS is slowly retired. This also suggests that they'll reveal new hardware - or at least a dose of it - at E3 2011. I don't suspect a hardware launch next year, but 2012 would basically be the absolute latest it could happen since there's essentially no way they'll be able to keep the Wii going with support beyond then (which is already dwindling, much like the Gamecube and N64 eras).
Take that all with a grain of salt as my personal prediction, because I have no info to go on other than what my silly brain can conjure up.