I would say yes! and here's why - if they could do it Grindhouse-style, with 4 different directors doing 30-minute segments for each of the "campaigns" and make it stylized as hell. Each director could use the same actors...or different actors to make it even more unique. I think it would be a cool idea to do something like that. And I'd rather see them use no-name actors too.
If it's a bigger-budget hollywood bullshit try at a whole story, then no.