Seiken Densetsu 3 would rock, since I've never got to play with traditional controls or truly translated version.
But yeah, the announcement sounds a lot bigger than just one game like Earthbound, the only things I can think it would be would be the unreleased Fire Emblems, Enix's Dragon Quest games, or maybe even retro classics with online support like Street Fighter or Mortal Kombat. Or Rare games - that would be huge, as well.
Or shit, maybe it's old Atari games... remember the Jaguar? 3DO, anyone? Sega CD? N64 disc drive? Arcade Games?! Throw MAME on that bitch and watch as billions pour in.