[quote name='tiredfornow']Do the Gates of Hell when you max out the Holy side. It makes those 50 waves a lot easier just spamming O(or B if you're playing on 360). Spam until you're about to do that super charged one, then a quick combo with square square (x x). Rinse, repeat, and you'll get it in no time.
I don't know about the original Dante's Inferno, but I don't remember anybody named Mohammed or Ali.[/QUOTE]
Gates of Hell got aggravating -- first try I get to wave 46, I think.
Then I figured out the real secret, if you want to do it and don't mind taking a bit of time.
You need the holy road maxed, or at least most of it.
Make sure you equip these four relics:
Magic Damage Increase
Ranged Weapon Damage Increase
Cross Increase Damage
Magic Regeneration
All should be at level 3.
Start a wave. Spam Martyrdom level 3 until everything is dead.
Wait around until your mana regenerates fully.
Start the next wave. Spam Martyrdom level 3 until everything is dead.
Wait around for mana to regenerate.
Rinse, repeat.
Until I got impatient and sick of waiting for mana regeneration, I think I had the clock up to something insane like 8:00.
You'll get a lot of health from the cross kills if you have the holy road maxed out... and the martyrdom kills make it so you complete the shit without taking damage so you end up getting +45 seconds every round.