I used to get "Nintendo Thumb" as we would call it from Street Fighter II on the SNES. best way to get rid of it is to use you hands for something else.
[quote name='the_deej']oh no, the shy guy game in mario party for 64 was hell on your hands[/QUOTE]
mario party was killer on my hands too, the analog stick was brutal when u had to just go clockwiser or counterclockwise. I would spin the hell out of it with my palm and my hand got blistered up.
The mini game in Mario Party where you had to light the lightbulb by peddaling a bicycle to repel a boo was such a bitch. I loved seeing the imprints of the N64 analog stick in my friends' palms.
Blisters usually just need time to heal on their own. Keep a blister clean and dry and cover it with a bandage until it goes away. While it heals, try to avoid putting pressure on the area or rubbing it.
I got that from google. btw quit pressing so hard. Last blister I had from gaming was NES and Super Mario 3. Two weeks straight I played that game for 8 hours or so a day me and my sister both could barley handle a fork or penicl after that ordeal.