[quote name='Mojimbo']
http://www.wikicheats.com/index.php/Fallout_3_-_PC_PS3_XB360/Character_Building
Don't put any of your SPECIAL stats to 10, there's a bobblehead collectable available for each that's a +1 so any more than 9 and it'll go to waste. Plus keep in mind that there are articles of clothing that can supplement your stats. I always carry different ones that give different boosts and equip them whenever necessary. For example, I have like five extra uniforms/suits that boost my repair/lockpicking/science/sneak/small arms skills by 5-10 points which comes in handy for skills that have requisites, like picking locks or hacking computers or repairing weapons.
I wouldn't bother with Luck at all. Put at least 4 points into Intelligence and purchase the Educated perk ASAP. I personally boosted my Strength so that I could carry more weight, Agility so I could be more effective in VATS, Endurance to up my HP and Intelligence to 9 boost my medicine/repair/science skills and so that when I level up I get 19 points minimum to spend instead of 11. The bobblehead for Intelligence is available early in the game when you get to Rivet City.
I would also avoid any perks that offer a direct XP bonus, there's a level cap of 20 which isn't hard to hit at all so you won't need any help with that.
Along the way you'll run into rare bottles of Quantum Nuke Cola. These are blueish and if you find any you should hold onto them. There's a quest that rewards you for collecting 30 of these. Same goes for "Pre-war Books", but instead of it being a quest there'll be a NPC that'll pay you 100 caps for each one you collect.
I would also look up the quest related perks since they're basically free stat boosts if you were gonna do the quest anyways.
http://www.wikicheats.com/index.php/Fallout_3_-_PC_PS3_XB360/Character_Building#Quest-Related_Perks[/quote]I can agree with all that
except the part about not bothering with Luck. I didn't touch it my first playthrough, but after adding it to a second character noticed that my critical hit frequency shot waaay up. Combined with the fact that having a good number of points towards Luck (6, I think) grants you access to the Scrounger perk - that lets you pickup considerably more ammo than you normally would - I'd say you don't want to completely ignore that S.P.E.C.I.A.L. attribute.