Oh yeah, I live in an area with 6 different counties and 2 cities with their own tax levies.
Depending on where the Target I'm buying shit from, I pay 7.125%(nearly everywhere), 7.275%(Hennepin County that's not Minneapolis), 7.625%(St. Paul) or 7.775%(Minneapolis). HC and Minny have a higher tax rate to pay for the Twins luxury palace, Target Field.
I try to not buy any taxable items in St. Paul, Hennepin County, or Minneapolis.