There's been a ton of great stuff from the last few years. I'm not much of a DC guy but several posters in the thread are, they could help you in that area.
Walking Dead lives up to the hype. Try tracking down the the Walking Dead compendium vol.1 which has the first 48 issues. Amazon has it for $35 which is a steal. That should keep you busy for a while.
Fables, Locke & Key, Y the Last Man, Chew, Preacher & Morning Glories are several of my favorite non-super hero comics. Defiantly check into Y the Last Man if anything.
As for Marvel super hero stuff Civil War is a nice starting point if you want to start getting caught up. I personally liked Civil War, but opinions are mixed. Annihilation is amazing if you like Marvel's cosmic stuff. Other recommendations Planet Hulk, Marvel 1602, Old Man Logan, World War Hulk, Immortal Iron Fist, Astonishing X-Men, Messiah Complex. The Ultimate Universe also has several great reads. Ultimates 1&2, the first 4 or 5 arcs of Ultimate FF and pretty much all of Ultimate Spidey has been good.
Let us know if you have any questions, we'll try to get you back reading.