I've finally started up DOA4 (cuz of the stick I got), and yeah, Alpha 152 is a bit ridiculous. She's too fast, too strong, and her grabs take away a big chunk of health. Ok, standard boss stuff... But then she also teleports! It seems like everytime I was about to connect a hit, BOOM, gone. Also, it doesn't help that my fighting game instincts are "hit hard, hit often" because everytime I'd go in, she'd hit me before I could hit her. But I did change my strategy a bit against her eventually, and I was able to just wipe her out in one go with Zack, so she's not SNK boss difficult.. At least not on the default difficulty.