About 25 hours into my insanity play through as an infiltrator, level 20 (I think?). I really cannot wait to get the Widow sniper rifle, which is coming up soon. I plan on upgrading everything I can, and doing all the side quests that I can find as this will most likely be the save that I carry over to ME3. I only missed 3 achievements the first time through, so that will be done as well. (lv 30, romance, insanity)
The thing that amazes me about this game (and the first), is that no matter how thoroughly you talk to everyone, click on everything, read the codex entries, etc, you always hear/learn new things on subsequent characters. Some of the jokes thrown in there are pretty good too (mock "gamestop" employee trying to rip you off, the ad for the elcor hamlet production, some of the e-mails).
I feel less obligated to stay strictly to paragon or renegade choices compared to ME1. This may be due to having achievements based off of them in ME1, or just the way it was handled, I dunno. My Shepard at the moment is mostly paragon with the occasional mean streak.
I will have the save I want to carry over and all achievements done after this play through. I really should move on to my backlog of games (dragon age, perhaps?), but that vanguard video really makes me want to play one of those through as a renegade. I had avoided vanguard in ME2, as that was the class I spent the most time on in ME1, but I see the similarities between the two games are few.